Plasmobase is a platform that compares the protein domain architectures found in the 11 Plasmodium fully sequenced genomes present in PlasmoDB, the reference repository for Plasmodium species. Plasmobase proposes a visualisation of domain architectures in all Plasmodium complete genomes and allows for an easy comparison among architectures in Plasmodium species and in all other species in Uniprot.

The architectures reported in Plasmobase were obtained by applying DAMA, a multi-objective approach that accurately resolves protein domain architectures. Domain annotation in Plasmobase is realised with CLADE (Closer sequences for Annotations Directed by Evolution), an annotation tool based on a multi-source strategy where several hundreds probabilistic profiles are used to annotate each Pfam domain, instead of one as for mono-source strategies using single probabilistic profiles based on consensus.